Bessières – En Naudou

Lien Atlas (MCC) :http://atlas.patrimoines.culture.fr/atlas/trunk/index.php?ap_theme=DOM_2.01.02&ap_bbox=1.543;43.771;1.626;43.817 Un projet de carrière pour l’extraction de granulats sur la commune de Bessières a déclenché un diagnostic archéologique sur une superficie de 130 000 m2, concernée par la première phase d’exploitation. Hors contraintes, la surface accessible était d’environ 126 175 m2. Les nombreuses structures mises au jour par ce diagnostic témoignent d’une longue occupation d..

Lanta – Canto Perlic

Un projet de construction d’un lotissement au lieu-dit « Canto Perlic » a enclenché un diagnostic archéologique sur une superficie de 30 221 m2. Selon les résultats du diagnostic, l’occupation la plus ancienne du site remonte au xie-xiie s. Elle est caractérisée par une fosse très arasée située au centre du secteur occidental. Un fossé moderne (xviie s. ?) traverse trois sondages, passant à proximité de la fosse médiévale. Les vestiges d’une briqueterie de l’ère industrielle ont été retrouvés..

Toulouse – 89-91 avenue Jules Julien

Lien Atlas (MCC) :http://atlas.patrimoines.culture.fr/atlas/trunk/index.php?ap_theme=DOM_2.01.02&ap_bbox=1.351;43.533;1.515;43.669 Un projet de construction d’un immeuble sur la commune de Toulouse a conduit à la réalisation d’un diagnostic archéologique sur une superficie de 719 m2 . Seule une superficie de 170 m2 s’est révélée effectivement accessible par les sondages, le terrain étant occupé en grande partie par le rez-de-chaussée de deux maisons et par leurs dépendances. Dans le sous-sol..

Toulouse – 89-91 avenue Jules Julien

Lien Atlas (MCC) :http://atlas.patrimoines.culture.fr/atlas/trunk/index.php?ap_theme=DOM_2.01.02&ap_bbox=1.351;43.533;1.515;43.669 Un projet de construction d’un immeuble sur la commune de Toulouse a conduit à la réalisation d’un diagnostic archéologique sur une superficie de 719 m2 . Seule une superficie de 170 m2 s’est révélée effectivement accessible par les sondages, le terrain étant occupé en grande partie par le rez-de-chaussée de deux maisons et par leurs dépendances. Dans le sous-sol..

Vieille-Toulouse – 9 chemin de Ventenac

Lien Atlas (MCC) :http://atlas.patrimoines.culture.fr/atlas/trunk/index.php?ap_theme=DOM_2.01.02&ap_bbox=1.421;43.513;1.453;43.546 Le projet d’agrandissement d’un immeuble sur la commune de Vieille-Toulouse a motivé un diagnostic archéologique sur une superficie de 5 697 m2, correspondant à la portion orientale du jardin de la maison existante. Le site se trouve au nord-ouest de la butte de Castéra, entre cette éminence et le centre urbain gaulois (plateau de La Planho). Le terrain est en fo..

3D Reconstruction, Digital Twinning, and Virtual Reality: Architectural Heritage Applications

Virtual Reality proposes different innovative solutions for the fruition of tangible, intangible, or no longer existing Cultural Heritage. The representation of architectural artifacts through virtual 3D models framed in immersive and interactive virtual environments allows building new paths of knowledge. This kind of narrative feeds the fruition, the understanding, and the involvement of the user. The article presents different examples of VR applied in the CH field, highlighting the VR capacities, foreshadowing possible future developments in the specific domain. The first case study describes the reconstructive digital modeling and the prototype application of VR aimed at rendering the interior space of the provisional hall of the First Italian Parliament, no longer existing, for the use of visitors to Palazzo Carignano in Turin. The second case study concerns the Charterhouse of Pisa in Calci and deals with two VR experiences realized for a new visit tour: 3D reconstruction of the illusory space depicted in a quadraturist frescoes and 3D representation of the layout of the cloister in its most important historical phases. The third case study deals with the reconstruction of the Cathedral of Carpi through a 3D interoperable BIM model and the new communication tool called “during time Digital Twin”, which uses a combination of VR and AR

As tensões entre a atuação subnacional e o governo Trump na questão imigratória: o caso das cidades-santuário

INCT - Instituto Nacional de Ciência e TecnologiaTrabalho de Conclusão de Curso (Graduação)Desde 20 de janeiro de 2017, quando Donald Trump assume a presidência dos Estados Unidos da América, percebe-se uma nova era no país tanto na área econômica, quanto política e social, levando a descontentamento nas diversas esferas da sociedade e do próprio governo. Dessa forma, o presente trabalho se propõe a analisar como vem ocorrendo as divergências entre a política migratória federal dos Estados Unidos com a das cidades-santuário ao longo da administração Trump, levando em consideração também a maneira com que a estrutura institucional federalista do país intensifica essas tensões, além de analisar o posicionamento que o judiciário estadunidense tem tido em relação a esses conflitos. Assim, esta pesquisa exploratória se utiliza do método histórico e de um estudo de caso específico para buscar suas conclusões. Ao final, percebe-se que a formação histórica dos EUA durante o período de centralização permite e muitas vezes intensifica a ocorrência de tensões entre os entes federativos, justamente pela existência de brechas constitucionais. A partir desse cenário que a luta contra as medidas anti-imigração do Presidente Trump se insere, ocorrendo através de medidas internas de protação ao imigrante e também externas, buscando combater diretamente as medidas federais. O judiciário, por fim, mostra uma tendência histórica de favorecimento da centralização, ou seja, a favor da esfera federal no que tange às disputas judiciais envolvendo essa matéria

GULASEKARAM, Pratheepan; RAMAKRISHNAN, Karthick S. The new immigration federalism. New York: Cambridge University Press, 2015.

Resenha crítica do livro "The new immigration federalism" (2015)

Mir-34a-5p Mediates Cross-Talk between M2 Muscarinic Receptors and Notch-1/EGFR Pathways in U87MG Glioblastoma Cells: Implication in Cell Proliferation

Glioblastoma (GBM) is the most aggressive human brain tumor. The high growth potential and decreased susceptibility to apoptosis of the glioma cells is mainly dependent on genetic amplifications or mutations of oncogenic or pro-apoptotic genes, respectively. We have previously shown that the activation of the M2 acetylcholine muscarinic receptors inhibited cell proliferation and induced apoptosis in two GBM cell lines and cancer stem cells. The aim of this study was to delve into the molecular mechanisms underlying the M2-mediated cell proliferation arrest. Exploiting U87MG and U251MG cell lines as model systems, we evaluated the ability of M2 receptors to interfere with Notch-1 and EGFR pathways, whose activation promotes GBM proliferation. We demonstrated that the activation of M2 receptors, by agonist treatment, counteracted Notch and EGFR signaling, through different regulatory cascades depending, at least in part, on p53 status. Only in U87MG cells, which mimic p53-wild type GBMs, did M2 activation trigger a molecular circuitry involving p53, Notch-1, and the tumor suppressor mir-34a-5p. This regulatory module negatively controls Notch-1, which affects cell proliferation mainly through the Notch-1/EGFR axis. Our data highlighted, for the first time, a molecular circuitry that is deregulated in the p53 wild type GBM, based on the cross-talk between M2 receptor and the Notch-1/EGFR pathways, mediated by mir-34a-5p

Hyperlipidemias and dietary patterns: transversal study of japanese brazilians

This study aimed at evaluating the association between hyperlipidemia and dietary patterns of Japanese Brazilians with and without hypothyroidism from Bauru, city in the State of São Paulo. We evaluated 1,330 individuals by means of demographic and dietary measurement, whom were gotten through standardized questionnaires previously tested. Clinical examination and laboratory data were anthropometry, blood pressure, fasting and 2-h glucose load, lipid profile and TSH and free T4. The chi-square and the odds ratio were used to evaluate associations between hyperlipidemia with studied variables. The prevalence of hyperlipidemia was 81.5% and it was associated with smokers, overweight, hypothyroid, hypertensive and glucose intolerants. We observed, in crude analysis, relationships with the presence of hyperlipidemia and fat saturated, oleic acid and dietary fiber from grains and cereals. After adjusting for the control variables, we observed relationships between hyperlipidemia (hypercholesterolemia and hypertriglyceridemia) with habitual intake of total fat, oleic acid, saturated fat, trans fat, dietary fiber and alcohol. As a conclusion, changes in the style of life, particularly in the dietary habits, can improve lipidic profile and that lipids intake can be a risk factor for hyperlipidemia. Prospectives studies will help test the hypothesis in Japanese Brazilians from Bauru.Este estudo teve como objetivo avaliar a associação entre hiperlipidemia e dieta de nipo-brasileiros de Bauru, município do Estado de São Paulo. Foram obtidos de 1.330 indivíduos dados mediante questionários previamente testados (dados demográficos e dietéticos). Os exames físicos e laboratoriais incluíram a coleta (ou dosagem) antropométrica, de pressão arterial, de glicemia de jejum e de 2 horas, de perfil lipídico e de TSH e T4 livre. Utilizaram-se teste qui-quadrado e medida de odds ratio para avaliar associação entre as variáveis estudadas e presença de hiperlipidemia. Foi encontrado 81,5% de hiperlipidêmicos e acometeu, principalmente, indivíduos tabagistas, com excesso de peso, hipotireoidismo, hipertensão arterial e intolerância a glicose. Observaram-se, mediante análise bruta, relações entre hiperlipidemia e ácido graxo saturado, ácido oléico e fibras de grãos e cereais. Após o ajuste para as variáveis de controle, observaram-se associações entre hiperlipidemia e consumo de lípides (totais, ácido oléico, saturados e trans), fibras e álcool. Conclui-se que mudanças no estilo de vida, particularmente no hábito alimentar, podem levar a uma melhora do quadro hiperlipidêmico e que o consumo de lípides pode ser um dos principais fatores para o aumento da hiperlipidemia. Estudos prospectivos auxiliarão para testar essas hipóteses nos nipo-brasileiros de Bauru.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Federal de São Paulo (UNIFESP) Departamento de Medicina PreventivaUniversidade Federal de São Paulo (UNIFESP) Departamento de MedicinaUNIFESP, Depto. de Medicina PreventivaUNIFESP, Depto. de MedicinaSciEL